Dr. J. Alexander Liddle Abstract:
Self-assembling systems hold great promise for the large-scale, low-cost production of functional nanostructures. DNA origami has revolutionized the fabrication of nucleic acid nanostructures, providing a straightforward route to arranging nanoscale objects such as Au nanoparticles, quantum dots, fluorophores, and biomolecules with nanometer precision and accuracy over 10 nm length scales.
In this short course, I will provide an overview of DNA nanofabrication methods, concentrating on DNA origami, and illustrating its potential with examples from our own research and the literature. I will describe approaches for integrating DNA origami with solid-state devices, and briefly discuss characterization and metrology techniques.
Bio:
J. Alexander Liddle received his BA and PhD in Materials Science from the University of Oxford. After his appointment in 1990 as a postdoctoral fellow at Bell Laboratories, he spent the next eleven years there, where his primary efforts were directed towards the research, development, and eventual commercialization of a novel electron-beam lithography technology. He is currently Scientific Director of the Microsystems and Nanotechnology Division at NIST. His division works in a variety of areas, ranging from quantum nanophotonics to biology. His personal research focus is on nanofabrication and self-assembly for nanomanufacturing. He has published over 250 papers, and holds 16 US patents, in areas ranging from electron-beam lithography to DNA-controlled nanoparticle assembly. He is a fellow of the APS and the Washington Academy of Sciences, and a member of the AVS and MRS. He has served on numerous advisory and program evaluation committees, including those for NSF, DOE, and the Semiconductor Research Corporation.